"Photoshop and Fireworks are great tools …for tweaking photos and creating icons, gradients and textures. When it comes to laying out web pages however, they are worse than substandard. They are actively harmful. They reinforce the incorrect idea that there is a way of representing the browsing experience in anything other than a browser.
What’s ironic is that designers who continue to shackle themselves to Photoshop and Fireworks do so because they claim that designing with HTML and CSS in the browser limits the design possibilities. And yet they are perfectly content to limit themselves to an environment where designs cannot be resized, cannot respond to varying text sizes and typefaces, and cannot convey even the most basic of interactions."

Adactio: Journal—Tools of a different trade